|
KMID : 0360319950270030482
|
|
Journal of Korean Cancer Research Association
1995 Volume.27 No. 3 p.482 ~ p.489
|
|
|
The Effect of Ginkgo Biloba Extract on Radiation Tumor Growth Delay in C3H Mouse Fibrosarcoma
|
|
|
|
|
Abstract
|
|
|
Ginkgo biloba extract(GBE), extract from leaves of Ginkgo biloba tree, is known to increase peripheral blood flow. Under the assumption that GBE would increase tumor blood flow and improve oxygen supply to the tumor and enhance radiation
sensitivity,
the effect of GBE on radiation tumor growth delay was investigated. C3H mouse fibrosarcoma(FSaII), 6 mm in size, growing in the hidleg muscle of C3H mouse was used. GBE was injected i.p. once 1 hr prior to irradiation or twice 25 hrs and 1 hr
prior
to
irradiation. Tumor growth was not influenced by GBE treatment alone. Tumor growth delay by a single dose of 50mg/kg and 100mg/kg of GBE plus 10Gy of radiation was prolonged to 1.23 times and to 1.36~1.49 times when compared with 10 Gy irradiation
alone.
Tumor growth delay by two doses of 100mg/kg of GBE plus 10 Gy of irradiation increased to 1.66~1.84 times(p<0.05). Radiation dose required for 3 day tumor growth delay decreased to half when two doses of 100mg/kg of GBE was given prior to
irradiation.
Based on these results, it is concluded that GBE enhances radiation sensitivity of C3H mouse fibrosarcoma(FSaII) and could be a potential radiosensitizer for the malignant tumor.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|